Description

n-Isopropyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, functionalized pyridine derivative containing a pinacol boronate ester group, making it a crucial advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block. Its molecular architecture is specifically designed for the efficient synthesis of complex molecules, offering a strategic handle for carbon-carbon bond formation. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity, reliable boronic ester reagents for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science & OLED Development: Employed in the creation of organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in OLEDs.
• Chemical Biology & Probe Development: Utilized as a precursor for synthesizing molecular probes and bioconjugation reagents due to its reactive boronate group.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and exploratory chemistry in academic and CRO laboratories.

Basic Information

Product Name	n-Isopropyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	1352414-62-0
Molecular Formula	C15H25BN2O2
Molecular Weight	276.19 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-(propan-2-ylamino)pyridine; 2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-isopropylpyridine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(isopropylamino)pyridine; 2-Pyridinamine, N-(1-methylethyl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; PINACOL [5-(ISOPROPYLAMINO)-4-METHYLPYRIDIN-2-YL]BORONATE
EINECS	Contact for details

Quality Control

Our production of n-Isopropyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity, critical for sensitive cross-coupling applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We operate under a cGMP-compliant quality management system, and our facilities are designed to meet the rigorous standards required for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.