Description

5-Iodopyrazolo[1,5-a]pyridine-3-carboxylic acid is a high-purity, heterocyclic carboxylic acid derivative featuring a strategically functionalized pyrazolopyridine core. This compound serves as a versatile and critical building block in modern organic synthesis, particularly for the development of novel pharmaceutical candidates and advanced materials. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable access to high-quality, complex intermediates for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of drug-like molecules, especially in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection products, leveraging its halogenated structure for further functionalization.
• Chemical Biology Probe Development: Serves as a precursor for creating labeled compounds or photoaffinity probes to study biological pathways and target engagement.
• Material Science: Potential building block for organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and carboxylic acid functionality.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex molecular architectures.
• Ligand Synthesis: Can be used to develop novel chelating ligands for catalysis or metal ion sensing applications.

Basic Information

Product Name	5-Iodopyrazolo[1,5-a]pyridine-3-carboxylic Acid
CAS No.	1352397-99-9
Molecular Formula	C8H5IN2O2
Molecular Weight	288.04 g/mol
Synonyms	5-Iodo-3-pyrazolo[1,5-a]pyridinecarboxylic acid; 5-Iodopyrazolo[1,5-a]pyridine-3-carboxylic acid; 3-Carboxy-5-iodopyrazolo[1,5-a]pyridine; 1352397-99-9; 5-Iodo-1H-pyrazolo[1,5-a]pyridine-3-carboxylic acid; Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 5-iodo-
EINECS	Contact for details

Quality Control

Our 5-Iodopyrazolo[1,5-a]pyridine-3-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.