Description

4-(Fmoc-Amino)-1-Methyl-4-Piperidinecarboxylic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a modified piperidine moiety. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled assembly of complex peptide chains.
• Pharmaceutical Research: Building block for the development of novel drug candidates, particularly in oncology, neurology, and metabolic disease research.
• Peptidomimetic Design: Used to incorporate constrained, non-natural amino acid structures that enhance peptide stability and bioavailability.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to identify new bioactive compounds.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Used in the synthesis of labeled peptides and probes for studying biological mechanisms and protein interactions.

Basic Information

Product Name	4-(Fmoc-Amino)-1-Methyl-4-Piperidinecarboxylic Acid
CAS No.	1352083-21-6
Molecular Formula	C23H26N2O4
Molecular Weight	394.47 g/mol
Synonyms	1-Methyl-4-[(9H-fluoren-9-ylmethoxy)carbonylamino]piperidine-4-carboxylic Acid; Fmoc-AMPP-OH; 4-(N-Fmoc-amino)-1-methylisonipecotic Acid; 4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1-methylpiperidine-4-carboxylic Acid; 4-(Fmoc-Amino)-1-methylpiperidine-4-carboxylic Acid; N-α-Fmoc-4-amino-1-methylpiperidine-4-carboxylic acid; 1-Methyl-4-(Fmoc-amino)piperidine-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of 4-(Fmoc-Amino)-1-Methyl-4-Piperidinecarboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and manufacturing applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.