Description

n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, especially those containing substituted pyridine cores.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety acts as a stable, reactive handle for forming carbon-carbon bonds with aryl halides under palladium catalysis.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of the 5-substituted-2-acetamidopyridine fragment into molecular scaffolds.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Ligand and Material Science Precursor: Can be utilized in the development of novel ligands for catalysis or as a precursor for functional organic materials.

Basic Information

Product Name	n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Acetamide
CAS No.	1351995-09-9
Molecular Formula	C14H21BN2O3
Molecular Weight	276.14 g/mol
Synonyms	2-Acetamido-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; N-[4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-amine, N-acetyl derivative; Acetamide, N-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-
EINECS	Contact for details

Quality Control

Our n-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Acetamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with client specifications and supporting regulatory filings for pre-clinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure to air is necessary, such as during weighing. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.