Description

1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidine-4-Carboxamide is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed reactions to form carbon-carbon bonds between aromatic rings, essential for creating complex molecular architectures.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) in drug discovery programs by providing a versatile handle for diversification.
• Ligand Synthesis: Serves as a precursor for the development of novel ligands used in catalysis or as pharmacophores.
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying biological targets and pathways.
• Material Science Research: Potential precursor for organic electronic materials or metal-organic frameworks (MOFs) due to its functionalized heterocyclic structure.

Basic Information

Product Name	1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidine-4-Carboxamide
CAS No.	1351995-05-5
Molecular Formula	C19H30BN3O3
Molecular Weight	359.27 g/mol
Synonyms	4-Piperidinecarboxamide, 1-[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 1-(4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperidine-4-carboxamide; 2-(4-Carbamoylpiperidin-1-yl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol [1-(4-Carbamoylpiperidin-1-yl)-4-methylpyridin-3-yl]boronate; CAS 1351995-05-5
EINECS	Contact for details

Quality Control

Our production of 1-(4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperidine-4-Carboxamide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.