Description

n-(4-Formyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methanesulfonamide is a high-value, multifunctional chemical building block that combines a pyridine core with both a formyl group and a protected boronic acid ester. This compound matters for its pivotal role in modern synthetic chemistry, enabling the construction of complex molecular architectures through Suzuki-Miyaura cross-coupling and other advanced reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used to build novel active ingredients for crop protection products, leveraging its boronic ester functionality for structural diversification.
• Material Science: Serves as a building block for creating functionalized polymers, ligands for catalysts, and organic electronic materials.
• Cross-Coupling Reactions: The pinacol boronic ester group is specifically designed for efficient palladium-catalyzed Suzuki-Miyaura cross-coupling with aryl halides.
• Chemical Synthesis: The formyl group provides a versatile handle for further derivatization via reductive amination, condensation, or nucleophilic addition reactions.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	n-(4-Formyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methanesulfonamide
CAS No.	1351277-22-9
Molecular Formula	C14H21BN2O5S
Molecular Weight	340.20 g/mol
Synonyms	2-[(Methanesulfonyl)amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinaldehyde; 5-Formyl-2-(methylsulfonamido)pyridine-3-boronic acid pinacol ester; 4-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl methanesulfonamide; N-[4-Formyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]methanesulfonamide; 1351277-22-9; Boronic ester pyridine aldehyde; Sulfonamide-protected pyridine boronic ester.
EINECS	Contact for details

Quality Control

Our production of n-(4-Formyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Methanesulfonamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation of the boronic ester functionality. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.