Description

4-Methyl-2-(2-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a sophisticated, high-value boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop new active ingredients and functional molecules. The CAS number for this compound is 1351206-46-6.

Application

This versatile boronic ester is a key intermediate in several high-growth industrial and research applications:

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used to create complex heterocyclic structures found in next-generation herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for constructing organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) for electronic and photonic applications.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and affinity tags for studying biological pathways and protein functions.
• Process Chemistry & Scale-up: Provides a reliable and stable boronate source for large-scale GMP manufacturing of complex organic molecules.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.

Basic Information

Product Name	4-Methyl-2-(2-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1351206-46-6
Molecular Formula	C18H29BN2O2
Molecular Weight	316.25 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-5-(2-methylpiperidin-1-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-2-(2-methyl-1-piperidinyl)pyridine; 4-Methyl-2-(2-methylpiperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 4-Methyl-2-(2-methylpiperidin-1-yl)pyridine-5-boronate; 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyridin-2-yl)-2-methylpiperidine; Boronic acid, B-[4-methyl-2-(2-methyl-1-piperidinyl)-5-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-(2-Methylpiperidin-1-Yl)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request. Our quality management system supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (argon or nitrogen) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.