Description

tert-Butyl (2-Bromo-3-Fluoropyridin-4-Yl)Methylcarbamate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, enabling the introduction of specific halogenated pyridine motifs into target molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• API Synthesis: Serves as a key fragment for constructing complex molecular architectures in active pharmaceutical ingredient (API) manufacturing.
• Chemical Biology Probes: Employed in the development of labeled compounds and probes for biochemical and pharmacological assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	tert-Butyl (2-Bromo-3-Fluoropyridin-4-Yl)Methylcarbamate
CAS No.	1350885-66-3
Molecular Formula	C11H14BrFN2O2
Molecular Weight	305.15 g/mol
Synonyms	Boc-4-(aminomethyl)-2-bromo-3-fluoropyridine; 1,1-Dimethylethyl N-[(2-bromo-3-fluoro-4-pyridinyl)methyl]carbamate; tert-Butyl N-[(2-bromo-3-fluoropyridin-4-yl)methyl]carbamate; 2-Bromo-3-fluoro-4-(Boc-aminomethyl)pyridine; (2-Bromo-3-fluoropyridin-4-yl)methylcarbamic acid tert-butyl ester; 4-(Boc-aminomethyl)-2-bromo-3-fluoropyridine; N-Boc-2-bromo-3-fluoro-4-pyridinemethanamine
EINECS	Contact for details

Quality Control

Our tert-Butyl (2-Bromo-3-Fluoropyridin-4-Yl)Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.