Description

[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-3-Yl)Methanone Dihydrochloride is a high-purity, pharmaceutically relevant chemical building block, specifically a dihydrochloride salt of a piperidine-pyridine derivative. This compound is valued for its role as a key synthetic intermediate in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on medicinal chemistry, particularly in the synthesis of compounds targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within drug discovery programs.
• Bioconjugation & Probe Development: The aminomethyl group provides a handle for conjugation, useful in creating chemical probes for biochemical assays.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in early-stage drug discovery.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for clinical trial material (CTM) and commercial API manufacturing.

Basic Information

Product Name	[4-(Aminomethyl)Piperidin-1-Yl](Pyridin-3-Yl)Methanone Dihydrochloride
CAS No.	1349719-00-1
Molecular Formula	C12H17N3O • 2HCl
Molecular Weight	292.21 g/mol (Free base: 219.29 g/mol)
Synonyms	1-[(Pyridin-3-yl)carbonyl]-4-(aminomethyl)piperidine dihydrochloride; (4-(Aminomethyl)piperidin-1-yl)(pyridin-3-yl)methanone dihydrochloride; 4-(Aminomethyl)-1-(3-pyridinylcarbonyl)piperidine dihydrochloride; 3-([4-(Aminomethyl)piperidin-1-yl]carbonyl)pyridine dihydrochloride; 1-(3-Pyridinecarbonyl)-4-(aminomethyl)piperidine dihydrochloride; 4-(Aminomethyl)-1-(pyridine-3-carbonyl)piperidine dihydrochloride; (Pyridin-3-yl)(4-(aminomethyl)piperidin-1-yl)methanone hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our [4-(Aminomethyl)Piperidin-1-Yl](Pyridin-3-Yl)Methanone Dihydrochloride is manufactured under strict quality control protocols suitable for research and development applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting key specifications such as assay, impurity profile, and residual solvents to ensure consistency and traceability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.