Description

tert-Butyl 4-(2-Chloro-4-Fluorobenzylamino)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a protected amine and a halogenated benzyl substituent. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily utilized by pharmaceutical R&D departments, contract research/manufacturing organizations (CROs/CMOs), and fine chemical manufacturers requiring a reliable and scalable source of this key building block.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperidine scaffold.
• Medicinal Chemistry Research: Serves as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CRO/CMO Manufacturing: Supplied to Contract Research and Manufacturing Organizations for custom synthesis and process development projects.
• Protease Inhibitor Development: Potential intermediate in the development of protease inhibitors due to its specific amine-protected structure.
• Chemical Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 4-(2-Chloro-4-Fluorobenzylamino)Piperidine-1-Carboxylate
CAS No.	1349717-69-6
Molecular Formula	C17H24ClFN2O2
Molecular Weight	342.84 g/mol
Synonyms	1-Boc-4-[(2-Chloro-4-fluorophenyl)methylamino]piperidine; tert-Butyl 4-[[(2-Chloro-4-fluorophenyl)methyl]amino]-1-piperidinecarboxylate; 4-[(2-Chloro-4-fluorobenzyl)amino]piperidine-1-carboxylic acid tert-butyl ester; N-[(2-Chloro-4-fluorophenyl)methyl]-4-piperidinamine, 1-(1,1-Dimethylethyl) 1,2-cyclohexanedicarboxylate; 1-Boc-4-((2-chloro-4-fluorobenzyl)amino)piperidine; Boc-4-(2-Chloro-4-fluorobenzylamino)piperidine; CAS 1349717-69-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Chloro-4-Fluorobenzylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.