Description

tert-Butyl (R)-(-)-2-Hydroxy-3,3-dimethylbutyrate is a high-value chiral building block and intermediate of significant importance in asymmetric synthesis. This compound is prized for its role in constructing complex molecules with defined stereochemistry, a critical requirement in modern pharmaceutical development. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly those targeting cardiovascular and central nervous system disorders.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of ligands for transition metal catalysts that facilitate stereoselective reactions.
• Agrochemical Synthesis: Serves as a building block for the development of chiral pesticides and herbicides with enhanced efficacy and environmental profiles.
• Fine Chemical Production: Employed in the manufacture of specialty flavors, fragrances, and advanced materials requiring specific stereochemical configurations.
• Academic & Industrial Research: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	tert-Butyl (R)-(-)-2-Hydroxy-3,3-dimethylbutyrate
CAS No.	1349685-12-6
Molecular Formula	C10H20O3
Molecular Weight	188.26 g/mol
Synonyms	(R)-(-)-2-Hydroxy-3,3-dimethylbutyric acid tert-butyl ester; (R)-tert-Butyl 2-hydroxy-3,3-dimethylbutanoate; (R)-HDBB; (R)-2-Hydroxy-3,3-dimethylbutyric acid tert-butyl ester; tert-Butyl (R)-2-hydroxy-3,3-dimethylbutanoate; (R)-O-t-Butyl 2-hydroxy-3,3-dimethylbutyrate; (2R)-2-Hydroxy-3,3-dimethylbutanoic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-(-)-2-Hydroxy-3,3-dimethylbutyrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, maintaining an inert atmosphere (e.g., under nitrogen or argon) is recommended to preserve stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.