Description

2-(Methylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is a high-value, multi-functional boronic ester derivative of a substituted nicotinonitrile. This compound matters as a critical pharmaceutical intermediate and Suzuki-Miyaura cross-coupling reagent, enabling the synthesis of complex molecules for drug discovery and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small molecule drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronate ester coupling partner for the formation of carbon-carbon bonds, essential in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Ligand and Catalyst Development: Acts as a precursor for creating novel ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-(Methylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile
CAS No.	1346809-48-0
Molecular Formula	C14H20BN3O2
Molecular Weight	273.14 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(methylamino)nicotinonitrile; 2-Methylamino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; 2-(Methylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarbonitrile; 2-(Methylamino)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; Pinacol 2-(Methylamino)-5-pyridylboronate; 5-Borono-2-(methylamino)nicotinonitrile pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(Methylamino)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.