Description

2-N, n-(Bis-Boc-Amino)-3-Methylpyridine-5-Boronic Acid Pinacol Ester is a sophisticated, high-purity boronic ester derivative, specifically engineered as a key building block in modern synthetic chemistry. Its value lies in providing a protected amine functionality and a stable boronic acid ester group, enabling precise and efficient cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, a cornerstone reaction in medicinal chemistry.
• Peptidomimetic & PROTAC Synthesis: Used in constructing complex peptide-like molecules and Proteolysis Targeting Chimeras (PROTACs) due to its protected amine and coupling-ready boronate.
• Agrochemical Research: Employed in developing novel crop protection agents and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Acts as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules to study biological pathways and protein function.

Basic Information

Product Name	2-N, n-(Bis-Boc-Amino)-3-Methylpyridine-5-Boronic Acid Pinacol Ester
CAS No.	1346808-71-6
Molecular Formula	C23H35BN2O6
Molecular Weight	446.35 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpyridin-2-amine, N,N-Bis(tert-butoxycarbonyl); 2-((Bis(tert-butoxycarbonyl)amino)-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-N,N-Bis-Boc-amino-3-methyl-5-pyridineboronic acid pinacol ester; 3-Methyl-2-((bis(tert-butoxycarbonyl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Bis-Boc-protected 3-Methyl-5-boronic acid pinacol ester pyridin-2-amine; CAS 1346808-71-6
EINECS	Contact for details

Quality Control

Our 2-N, n-(Bis-Boc-Amino)-3-Methylpyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and LC-MS to confirm identity, purity, and the absence of critical impurities. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.