Description

(1R,4R)-4-(Methylamino)Cyclohexyl2-Hydroxy-2,2-Di(Thiophen-2-Yl)Acetate is a high-purity, chiral organic compound of significant interest in advanced pharmaceutical research and development. Its unique molecular architecture, featuring a cyclohexyl backbone, methylamino group, and two thiophene rings, makes it a valuable key intermediate or building block for synthesizing novel active pharmaceutical ingredients (APIs). This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and synthesis of new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Agrochemical Research: Used as a building block for developing novel pesticides or herbicides, leveraging the thiophene moiety for potential biological activity.
• Ligand and Catalyst Development: The structure can be utilized to create novel chiral ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Material Science Precursor: Acts as a monomer or functionalizing agent in the development of advanced organic electronic materials or polymers.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting cutting-edge organic and medicinal chemistry projects.
• Process Chemistry & Scale-Up: Supplied for process optimization and pilot-scale production runs under cGMP (current Good Manufacturing Practice) guidelines where applicable.

Basic Information

Product Name	(1R,4R)-4-(Methylamino)Cyclohexyl2-Hydroxy-2,2-Di(Thiophen-2-Yl)Acetate
CAS No.	1346762-52-4
Molecular Formula	C₁₇H₂₁NO₃S₂
Molecular Weight	351.48 g/mol
Synonyms	(1R,4R)-4-(Methylamino)cyclohexyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate; 2-Hydroxy-2,2-di(2-thienyl)acetic Acid (1R,4R)-4-(Methylamino)cyclohexyl Ester; (1R,4R)-4-(Methylamino)cyclohexyl α-Hydroxy-α,α-di-2-thienylacetate; 4-(Methylamino)cyclohexanol, 2,2-di-2-thienylglycolate (trans-); trans-4-(Methylamino)cyclohexyl 2,2-di(thiophen-2-yl)-2-hydroxyacetate; (1R,4R)-rel-4-(Methylamino)cyclohexyl 2-hydroxy-2,2-di-2-thienylacetate; Building Block 1346762-52-4; Chiral Cyclohexylamine Ester Derivative
EINECS	Contact for details

Quality Control

Our (1R,4R)-4-(Methylamino)Cyclohexyl2-Hydroxy-2,2-Di(Thiophen-2-Yl)Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification via NMR, IR, and MS, to ensure it meets exacting R&D and process chemistry standards. Certificates of Analysis (COA) with full analytical data are provided for each shipment. We support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.