Description

2-Ethyl-5-(Trifluoromethyl)Pyrazole-3-Boronic Acid is a high-value organoboron building block, specifically a pyrazole-substituted boronic acid. This compound is critical for modern synthetic chemistry, enabling the formation of carbon-carbon bonds via the Suzuki-Miyaura cross-coupling reaction. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs) with tailored properties.
• Cross-Coupling Reactions: An essential reagent for Suzuki-Miyaura cross-coupling, facilitating the efficient and selective introduction of the pyrazole moiety into complex molecular architectures.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug-like molecules for high-throughput screening and structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Product Name	2-Ethyl-5-(Trifluoromethyl)Pyrazole-3-Boronic Acid
CAS No.	1346665-27-7
Molecular Formula	C6H8BF3N2O2
Molecular Weight	207.95 g/mol
Synonyms	[2-Ethyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]boronic acid; 2-Ethyl-5-(trifluoromethyl)-1H-pyrazole-3-boronic acid; 3-Borono-2-ethyl-5-(trifluoromethyl)pyrazole; 2-Ethyl-5-trifluoromethyl-1H-pyrazole-3-boronic acid; 5-(Trifluoromethyl)-2-ethyl-1H-pyrazole-3-boronic acid; B-[2-Ethyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]boronic acid; 2-Ethyl-5-(trifluoromethyl)pyrazole-3-boronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 2-Ethyl-5-(Trifluoromethyl)Pyrazole-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.