Description

6-Cyclopropyl-2-Hydroxy-4-Methylnicotinonitrile is a high-value, functionalized pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a cyclopropyl group and a nitrile moiety, makes it an essential intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Precursor: Employed in the research of organic electronic materials and functional polymers due to its electron-deficient pyridine ring.
• Chemical Biology Probe Development: Utilized to build molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific nitrile derivative.

Basic Information

Product Name	6-Cyclopropyl-2-Hydroxy-4-Methylnicotinonitrile
CAS No.	1346576-02-0
Molecular Formula	C10H10N2O
Molecular Weight	174.20 g/mol
Synonyms	2-Hydroxy-4-methyl-6-cyclopropylnicotinonitrile; 4-Methyl-6-cyclopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile; 6-Cyclopropyl-4-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; 2-Hydroxy-6-cyclopropyl-4-methyl-3-cyanopyridine; 3-Cyano-6-cyclopropyl-4-methyl-2(1H)-pyridinone
EINECS	Contact for details

Quality Control

Every batch of 6-Cyclopropyl-2-Hydroxy-4-Methylnicotinonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.