Description

Methyl 6-(Trifluoromethyl)Nicotinoylacetate is a high-value trifluoromethylated nicotinate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the unique reactivity and metabolic stability imparted by the trifluoromethyl group, making it indispensable for constructing complex molecular architectures. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Potential monomer or additive in the development of advanced polymers with specific fluorinated properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Methyl 6-(Trifluoromethyl)Nicotinoylacetate
CAS No.	1346534-09-5
Molecular Formula	C10H8F3NO3
Molecular Weight	247.17 g/mol
Synonyms	Methyl 2-oxo-2-[6-(trifluoromethyl)pyridin-3-yl]acetate; 3-Pyridineacetic acid, 6-(trifluoromethyl)-, methyl ester; Methyl (6-(trifluoromethyl)nicotinoyl)acetate; 6-(Trifluoromethyl)nicotinoylacetic acid methyl ester; Methyl 6-(trifluoromethyl)-3-pyridinylglyoxylate
EINECS	Contact for details

Quality Control

Our Methyl 6-(Trifluoromethyl)Nicotinoylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.