Description

(E)-Methyl 3-(3,4-Dihydro-2H-Pyrano-[2,3-B]Pyridin-6-Yl)Acrylate is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry, crucial for the synthesis of complex bioactive molecules. Its core value lies in serving as a versatile building block for constructing fused heterocyclic systems prevalent in modern drug discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating novel small-molecule therapeutics and crop protection agents. The consistent quality and reliable supply of this intermediate are critical for accelerating R&D timelines and ensuring process reproducibility.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates targeting various disease pathways.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or insecticides with complex heterocyclic cores.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating molecular tools to study biological processes and protein function.
• Material Science Research: Potential monomer or precursor for specialty polymers with unique optical or electronic properties.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and novel compound library synthesis.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production for clinical trial material (CTM) manufacturing.

Basic Information

Item	Detail
Product Name	(E)-Methyl 3-(3,4-Dihydro-2H-Pyrano-[2,3-B]Pyridin-6-Yl)Acrylate
CAS No.	1346451-50-0
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	Methyl (2E)-3-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)prop-2-enoate; (E)-Methyl 3-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)acrylate; Methyl (E)-3-(3,4-Dihydro-2H-pyrano[2,3-b]pyridin-6-yl)acrylate; 6-[(1E)-3-Methoxy-3-oxo-1-propen-1-yl]-3,4-dihydro-2H-pyrano[2,3-b]pyridine; (E)-Methyl 3-(3,4-dihydro-2H,2'H-[2,3'-bipyrano]-6-yl)acrylate (alternative ring naming); Acrylic acid, 3-(3,4-dihydro-2H-pyrano[2,3-b]pyridin-6-yl)-, methyl ester, (E)-
EINECS	Contact for details

Quality Control

Our (E)-Methyl 3-(3,4-Dihydro-2H-Pyrano-[2,3-B]Pyridin-6-Yl)Acrylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.