Description

n-(3-Cyano-5-Fluoropyridin-2-Yl)Pivalamide is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core functionalized with cyano and fluoro substituents. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted drug candidates with enhanced potency and selectivity. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drugs, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents, leveraging its fluorinated pyridine structure for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies in academic and industrial labs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the synthesis of final drug substances, requiring strict control over purity and impurities.
• Contract Manufacturing (CMO/CDMO): Supplied to outsourcing partners for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	n-(3-Cyano-5-Fluoropyridin-2-Yl)Pivalamide
CAS No.	1346447-40-2
Molecular Formula	C11H12FN3O
Molecular Weight	221.23 g/mol
Synonyms	2-Pivalamido-5-fluoro-3-cyanopyridine; Pivalic acid (5-fluoro-3-cyano-2-pyridinyl)amide; 5-Fluoro-2-(pivaloylamino)nicotinonitrile; N-(5-Fluoro-3-cyano-2-pyridinyl)-2,2-dimethylpropanamide; 1346447-40-2; 2-Amino-5-fluoro-3-cyanopyridine pivalate; Pivaloyl-5-fluoro-3-cyano-2-aminopyridine
EINECS	Contact for details

Quality Control

Our n-(3-Cyano-5-Fluoropyridin-2-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor quality standards to meet specific cGMP or ISO requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere if necessary for long-term storage. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.