Description

n-(5-Fluoro-3-Hydroxypyridin-2-Yl)Pivalamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine-based structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Fluorinated Compound Synthesis: Serves as a precursor for the development of other fluorinated heterocyclic compounds due to its stable fluorine substituent.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis and scale-up projects.
• Biochemical Research: Potential use as a probe or inhibitor in biochemical assays targeting specific enzymatic pathways.

Basic Information

Product Name	n-(5-Fluoro-3-Hydroxypyridin-2-Yl)Pivalamide
CAS No.	1346447-10-6
Molecular Formula	C10H13FN2O2
Molecular Weight	212.22 g/mol
Synonyms	2-Pivalamido-5-fluoro-3-hydroxypyridine; Pivalic Acid (5-Fluoro-3-hydroxy-2-pyridinyl)amide; 5-Fluoro-3-hydroxy-N-(2,2-dimethyl-1-oxopropyl)-2-pyridinecarboxamide; 1346447-10-6; 5-Fluoro-3-hydroxypyridine-2-carboxamide, N-(tert-butylcarbonyl); N-(5-Fluoro-3-hydroxypyridin-2-yl)-2,2-dimethylpropanamide
EINECS	Contact for details

Quality Control

Our n-(5-Fluoro-3-Hydroxypyridin-2-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.