Description

(S)-Methyl 2-(2,3-Bis(Hydroxymethyl)-6,7-Dihydrothieno[3,2-C] Pyridin-5(4H)-Yl)-2-(2-Chlorophenyl)Acetate CAS NO 1346231-36-4 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its complex molecular architecture, which serves as a critical building block for the development of advanced active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions, contract research/manufacturing organizations (CROs/CMOs), and pharmaceutical companies engaged in the discovery and production of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for constructing complex, biologically active molecules during preclinical and clinical development stages.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to introduce specific chiral centers, ensuring the production of the desired enantiomerically pure compound.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Used in developing and optimizing robust, scalable synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Acts as a high-purity analytical standard for quality control (QC) and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	(S)-Methyl 2-(2,3-Bis(Hydroxymethyl)-6,7-Dihydrothieno[3,2-C] Pyridin-5(4H)-Yl)-2-(2-Chlorophenyl)Acetate
CAS No.	1346231-36-4
Molecular Formula	C20H22ClNO4S
Molecular Weight	407.91 g/mol
Synonyms	(S)-Methyl 2-(2,3-Bis(hydroxymethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate; (S)-5-[(2-Chlorophenyl)(methoxycarbonyl)methyl]-2,3-bis(hydroxymethyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine; Prasugrel Intermediate; Prasugrel Related Compound; Thienopyridine Derivative; (S)-Prasugrel Acid Methyl Ester (common name for related structure); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-(2,3-Bis(Hydroxymethyl)-6,7-Dihydrothieno[3,2-C] Pyridin-5(4H)-Yl)-2-(2-Chlorophenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (HPLC), chemical purity (HPLC), and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment. We can supply material compliant with ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.