Description

tert-Butyl 4-Oxo-1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing novel chemical libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for potential new chemical entities (NCEs).
• Academic & Institutional R&D: Employed in university and research institute laboratories for exploring new synthetic methodologies and bio-active molecules.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	tert-Butyl 4-Oxo-1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate
CAS No.	1346229-51-3
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	9-Boc-4-oxo-1-oxa-9-azaspiro[5.5]undecane; 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-oxo-, 1,1-dimethylethyl ester; tert-Butyl 4-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 4-Oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; Boc-Protected 4-Oxo-1-Oxa-9-Azaspiro[5.5]Undecane; BOC-1-Oxa-9-Azaspiro[5.5]Undecane-4-one-9-Carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Oxo-1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP guidelines for applications requiring the highest regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.