Description

Methyl 5-Fluoro-3-Methylpicolinate CAS NO 1346148-32-0 is a high-purity, fluorinated picolinate ester derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its unique molecular structure, which provides a versatile chemical handle for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on novel active ingredients, where precise functional group manipulation is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Material Science Precursor: Potential intermediate in the synthesis of specialized ligands for catalysts or functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in multi-step synthetic routes for client projects.

Basic Information

Product Name	Methyl 5-Fluoro-3-Methylpicolinate
CAS No.	1346148-32-0
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	5-Fluoro-3-methylpyridine-2-carboxylic acid methyl ester; Methyl 5-fluoro-3-methyl-2-pyridinecarboxylate; 2-Pyridinecarboxylic acid, 5-fluoro-3-methyl-, methyl ester; 3-Methyl-5-fluoropicolinic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-Fluoro-3-Methylpicolinate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.