Description

Methyl 1-[(4-Fluorophenyl)Carbamoyl]Cyclopropanecarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring and a fluorinated aromatic amide moiety. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry and bioactivity. It is primarily sought by R&D laboratories and production facilities in the pharmaceutical and agrochemical sectors for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary drug candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Serves as a core scaffold for developing new herbicides and fungicides with enhanced efficacy and environmental profiles.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme inhibition and receptor-ligand interactions due to its defined stereochemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up under cGMP conditions for clinical trial material production.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	Methyl 1-[(4-Fluorophenyl)Carbamoyl]Cyclopropanecarboxylate
CAS No.	1345847-71-3
Molecular Formula	C12H12FNO3
Molecular Weight	237.23 g/mol
Synonyms	Methyl 1-[(4-fluorophenyl)carbamoyl]cyclopropanecarboxylate; 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic acid methyl ester; Cyclopropanecarboxylic acid, 1-[(4-fluorophenyl)aminocarbonyl]-, methyl ester; Methyl 1-(4-fluorophenylcarbamoyl)cyclopropanecarboxylate; 1345847-71-3; Methyl N-(4-fluorophenyl)cyclopropane-1,1-dicarboximidate
EINECS	Contact for details

Quality Control

Our Methyl 1-[(4-Fluorophenyl)Carbamoyl]Cyclopropanecarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring material for GLP (Good Laboratory Practice) and cGMP (current Good Manufacturing Practice) environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.