Description

1-{2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Ethyl}Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a pyrazole ring linked to a pyrrolidinone moiety via an ethyl spacer and protected with a pinacol boronate ester group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in areas like kinase inhibitors and targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted cancer therapies and other specialty medicines.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group makes it an excellent reagent for palladium-catalyzed coupling reactions to form carbon-carbon bonds, a fundamental step in constructing complex organic molecules.
• Medicinal Chemistry & Drug Discovery: Used extensively in research labs for constructing molecular libraries and optimizing lead compounds, especially those targeting protein kinases.
• Bioconjugation & Probe Development: Can be utilized in the development of chemical probes and bioconjugates for biochemical assays and diagnostic applications.
• Agrochemical Research: Acts as an intermediate in the research and development of novel agrochemicals with specific biological activities.
• Material Science: Potential use as a monomer or functional additive in the synthesis of specialty polymers with tailored properties.

Basic Information

Product Name	1-{2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Ethyl}Pyrrolidin-2-One
CAS No.	1342834-87-0
Molecular Formula	C15H26BN3O3
Molecular Weight	307.20 g/mol
Synonyms	1-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]pyrrolidin-2-one; 1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one; 1-[2-[4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]-2-pyrrolidinone; 2-Pyrrolidinone, 1-[2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl]-; 1-(2-(4-(Pinacolboryl)-1H-pyrazol-1-yl)ethyl)pyrrolidin-2-one; 4-(Pinacolboryl)-1-(2-(2-oxopyrrolidin-1-yl)ethyl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1-{2-[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Ethyl}Pyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.