Description

Ethyl 4-(2,6-Difluorophenyl)-2-Hydroxy-4-Oxobut-2-Enoate is a high-purity, advanced pharmaceutical intermediate characterized by its β-keto ester and difluorophenyl functional groups. This compound matters for its critical role as a versatile building block in the synthesis of complex, biologically active molecules, enabling precise structural modifications. It is primarily needed by research and development teams and process chemists in the pharmaceutical and agrochemical industries for creating new active ingredients and fine-tuning the properties of existing ones.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a building block for developing new generation herbicides and fungicides, where the difluorophenyl moiety can enhance biological activity and environmental stability.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new reaction pathways, such as Michael additions and cyclizations, to create diverse heterocyclic compounds.
• Material Science Precursor: Potential use in the synthesis of specialized monomers or ligands for advanced materials and catalysts.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines for clinical trial materials.

Basic Information

Product Name	Ethyl 4-(2,6-Difluorophenyl)-2-Hydroxy-4-Oxobut-2-Enoate
CAS No.	1342259-34-0
Molecular Formula	C₁₂H₁₀F₂O₄
Molecular Weight	256.20 g/mol
Synonyms	Ethyl 2,6-difluoro-β-oxobenzeneacetate; Ethyl (2Z)-4-(2,6-difluorophenyl)-2-hydroxy-4-oxo-2-butenoate; 2-Butenoic acid, 4-(2,6-difluorophenyl)-2-hydroxy-4-oxo-, ethyl ester; Ethyl 4-oxo-4-(2,6-difluorophenyl)-2-hydroxybut-2-enoate; (Z)-Ethyl 4-(2,6-difluorophenyl)-2-hydroxy-4-oxobut-2-enoate
EINECS	Contact for details

Quality Control

Our Ethyl 4-(2,6-Difluorophenyl)-2-Hydroxy-4-Oxobut-2-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production can be aligned with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.