Description

Ethyl 4-((tert-Butyldimethylsilyl)oxy)-3-oxobutanoate is a high-value, protected β-ketoester derivative that serves as a critical synthetic building block in advanced organic chemistry. Its core value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which provides exceptional stability for sensitive ketone functionalities during complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of active pharmaceutical ingredients (APIs), complex natural products, and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex drug molecules, especially those containing β-ketoester or 1,3-dicarbonyl motifs.
• Peptide Mimetics & Prodrug Synthesis: Used in the construction of peptide analogs and prodrugs where the protected keto group is crucial for bioavailability and metabolic stability.
• Natural Product Synthesis: Facilitates the stereoselective synthesis of complex natural products like polyketides, macrolides, and alkaloids.
• Asymmetric Catalysis Substrate: Serves as a substrate for developing and testing new asymmetric catalytic reactions due to its prochiral center.
• Material Science Precursor: Potential precursor for organic ligands or monomers used in advanced polymeric materials.
• Chemical Biology Probes: Used to create tagged or modified chemical probes for studying biological pathways and enzyme mechanisms.

Basic Information

Item	Detail
Product Name	Ethyl 4-((tert-Butyldimethylsilyl)oxy)-3-oxobutanoate
CAS No.	1341195-54-7
Molecular Formula	C12H24O4Si
Molecular Weight	260.41 g/mol
Synonyms	Ethyl 4-(tert-Butyldimethylsilyloxy)-3-oxobutanoate; Ethyl 3-Oxo-4-[(tert-butyldimethylsilyl)oxy]butyrate; 4-(tert-Butyldimethylsiloxy)-3-oxobutanoic Acid Ethyl Ester; TBDMS-protected Ethyl Acetoacetate; Ethyl 4-(TBDMSO)-3-oxobutanoate; 3-Oxo-4-[(tert-butyldimethylsilyl)oxy]butanoic Acid Ethyl Ester; Ethyl 4-(tert-Butyldimethylsilyloxy)acetoacetate
EINECS	Contact for details

Quality Control

Our Ethyl 4-((tert-Butyldimethylsilyl)oxy)-3-oxobutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to strong acid/organic solvent and fluoride/strong alkali conditions. Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.