Description

2-(tert-Butoxycarbonyl)-2-Azaspiro[4.4]Nonane-7-Carboxylic Acid is a high-value, protected spirocyclic amino acid derivative used as a critical building block in advanced organic synthesis. Its rigid, three-dimensional spirocyclic structure makes it an essential intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily utilized by pharmaceutical and biotechnology research organizations for the development of novel therapeutics, including protease inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor research.
• Peptidomimetics Development: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and binding affinity.
• Medicinal Chemistry: Serves as a versatile scaffold in drug discovery programs for creating focused libraries and lead optimization.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis due to its defined chiral center and spirocyclic framework.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clients.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-2-Azaspiro[4.4]Nonane-7-Carboxylic Acid
CAS No.	1341037-89-5
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	Boc-2-Azaspiro[4.4]nonane-7-carboxylic Acid; 7-Carboxy-2-azaspiro[4.4]nonane-2-carboxylic Acid 1,1-Dimethylethyl Ester; 2-[(Tert-Butoxy)carbonyl]-2-azaspiro[4.4]nonane-7-carboxylic Acid; 2-Boc-2-Azaspiro[4.4]nonane-7-Carboxylic Acid; 2-Azaspiro[4.4]nonane-7-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-; (7S)-2-[(Tert-Butoxy)carbonyl]-2-azaspiro[4.4]nonane-7-carboxylic Acid (for specific enantiomer); tert-Butyl 7-carboxy-2-azaspiro[4.4]nonane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-2-Azaspiro[4.4]Nonane-7-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive pharmaceutical research. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere or with appropriate desiccant to maintain stability. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.