Description

1-[(tert-Butoxy)Carbonyl]-1H,2H,3H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a fused pyrrolopyridine scaffold protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead conjugates due to its functional handle for further derivatization.
• Kinase Inhibitor Synthesis: A crucial precursor in the manufacturing of targeted kinase inhibitors, leveraging the pyrrolopyridine core's affinity for ATP-binding sites.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial batch synthesis under cGMP guidelines.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic chemistry and novel synthetic methodology development.

Basic Information

Product Name	1-[(tert-Butoxy)Carbonyl]-1H,2H,3H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid
CAS No.	1341037-48-6
Molecular Formula	C₁₃H₁₆N₂O₄
Molecular Weight	264.28 g/mol
Synonyms	1H,2H,3H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-Boc-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-N-Boc-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydropyrrolo[2,3-b]pyridine-5-carboxylic Acid; 1,2,3,4-Tetrahydropyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[(tert-butoxy)carbonyl]-; Boc-THP-pyridine-5-COOH; CAS 1341037-48-6
EINECS	Contact for details

Quality Control

Our production of 1-[(tert-Butoxy)Carbonyl]-1H,2H,3H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced synthetic applications. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support development under quality agreements and can supply material manufactured in compliance with ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.