Description

tert-Butyl 7-(Aminomethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate is a high-value, protected amine intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of new drug candidates, particularly in the areas of central nervous system (CNS) and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Peptidomimetic Synthesis: The spirocyclic and amine functionalities make it suitable for creating conformationally constrained peptide analogs.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Library Synthesis for High-Throughput Screening (HTS): Employed to generate diverse compound libraries for biological screening.

Basic Information

Product Name	tert-Butyl 7-(Aminomethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate
CAS No.	1341036-75-6
Molecular Formula	C14H26N2O2
Molecular Weight	254.37 g/mol
Synonyms	2-Azaspiro[4.4]nonane-2-carboxylic acid, 7-(aminomethyl)-, 1,1-dimethylethyl ester; 7-(Aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate; 2-Azaspiro[4.4]nonane-2-carboxylic acid, 7-(aminomethyl)-, tert-butyl ester; Boc-2-aza-7-aminomethyl-spiro[4.4]nonane; (7-(Aminomethyl)-2-azaspiro[4.4]nonan-2-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(Aminomethyl)-2-Azaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data including HPLC purity, NMR (¹H and ¹³C), and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.