Description

2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester 8-Ethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a constrained spirocyclic scaffold. This compound is valued for its role as a key building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules with improved metabolic stability and target selectivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutics, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for bifunctional molecules that induce targeted protein degradation.
• Chemical Biology Probes: Employed in the creation of tool compounds for investigating biological mechanisms and target validation.
• Peptidomimetic Drug Design: The spirocyclic diaza structure mimics peptide turn motifs, useful in developing stable, drug-like molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery and development pipelines.

Basic Information

Item	Details
Product Name	2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester 8-Ethyl Ester
CAS No.	1341035-13-9
Molecular Formula	C15H24N2O4
Molecular Weight	296.36 g/mol
Synonyms	2,6-Diaza-spiro[3.4]octane-2,8-dicarboxylic acid, 2-(1,1-dimethylethyl) 8-ethyl ester; 2-(tert-Butyl) 8-ethyl 2,6-diaza-spiro[3.4]octane-2,8-dicarboxylate; 2,6-Diaza-spiro[3.4]octane-2,8-dicarboxylic acid, 2-tert-butyl ester 8-ethyl ester; 2-tert-Butoxycarbonyl-6-ethoxycarbonyl-2,6-diaza-spiro[3.4]octane; Boc-2,6-Diaza-spiro[3.4]octane-8-COOEt; 2,6-Diaza-spiro[3.4]octane-2,8-dicarboxylate derivative; Spirocyclic diaza building block.
EINECS	Contact for details

Quality Control

Our 2,6-Diaza-Spiro[3.4]Octane-2,8-Dicarboxylic Acid 2-tert-Butyl Ester 8-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.