Description

2-Cyano-5-Fluoro-Nicotinic Acid tert-Butyl Ester is a high-value pyridine derivative and a key pharmaceutical intermediate. This compound is specifically designed for the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals, offering a versatile building block for medicinal chemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for advanced R&D and production processes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its fluorinated pyridine core.
• Chemical Research & Development: Serves as a versatile precursor for creating complex heterocyclic compounds in academic and industrial labs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and functional materials.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects.

Basic Information

Product Name	2-Cyano-5-Fluoro-Nicotinic Acid tert-Butyl Ester
CAS No.	1341034-65-8
Molecular Formula	C11H11FN2O2
Molecular Weight	222.22 g/mol
Synonyms	tert-Butyl 2-cyano-5-fluoropyridine-3-carboxylate; 5-Fluoro-2-cyanonicotinic acid tert-butyl ester; 3-Pyridinecarboxylic acid, 2-cyano-5-fluoro-, 1,1-dimethylethyl ester; 2-Cyano-5-fluoropyridine-3-carboxylic acid tert-butyl ester; 1341034-65-8; tert-Butyl 5-fluoro-2-cyanonicotinate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, and we adhere to strict quality management protocols suitable for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.