Description

tert-Butyl 8-Oxo-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel spirocyclic drug candidates targeting protease enzymes and GPCRs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• API Development: Integral in the research and process development stages for new chemical entities (NCEs), especially those requiring constrained, three-dimensional structures.
• Chemical Biology Probes: Serves as a core structure for developing selective enzyme inhibitors or receptor modulators used as research tools.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex therapeutic molecules.

Basic Information

Item	Details
Product Name	tert-Butyl 8-Oxo-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1340481-95-9
Molecular Formula	C11H17NO3S
Molecular Weight	243.32 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-8-oxo-6-thia-2-azaspiro[3.4]octane; tert-Butyl 8-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate (related); 8-Oxo-6-thia-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; Boc-protected spirocyclic thiazaoctanone; Spiro[3.4]octane-2-carboxylate derivative; 1340481-95-9; CAS 1340481-95-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Oxo-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.