Description

tert-Butyl 8-Hydroxy-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 6,6-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic sulfonamide structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug molecules, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes from laboratory to pilot and commercial production scales.
• API Synthesis: Incorporated into the synthetic pathway of complex target molecules, leveraging its spirocyclic and sulfonamide functionalities.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology and bioorganic chemistry.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 6,6-Dioxide
CAS No.	1340481-94-8
Molecular Formula	C11H19NO5S
Molecular Weight	277.34 g/mol
Synonyms	8-Hydroxy-6-thia-2-azaspiro[3.4]octane-2-carboxylic acid, 1,1-dimethylethyl ester, 6,6-dioxide; tert-Butyl 8-hydroxy-6-thia-2-azaspiro[3.4]octane-2-carboxylate S,S-dioxide; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-hydroxy-6-thia-, 1,1-dimethylethyl ester, 6,6-dioxide; Spirocyclic Sulfonamide Intermediate; 1340481-94-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Hydroxy-6-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 6,6-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.