Description

tert-Butyl 8-Oxo-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic sulfonamide structure. This compound is of significant value in modern medicinal chemistry for constructing complex molecular scaffolds with potential biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for synthesizing novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Protease Inhibitor Scaffold: Used in the research and development of protease inhibitor candidates, leveraging the sulfonamide and spirocyclic motifs.
• Library Synthesis for High-Throughput Screening: Employed in combinatorial chemistry to generate diverse compound libraries for biological screening against various disease targets.
• Chemical Biology Probe Development: Acts as a core structure for developing chemical probes to study enzyme function and protein-protein interactions.
• Process Chemistry & Route Scouting: Utilized in optimizing synthetic routes for scale-up and manufacturing processes of complex drug molecules.
• Academic Research: Used in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 8-Oxo-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide
CAS No.	1340481-91-5
Molecular Formula	C11H17NO5S
Molecular Weight	275.32 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-8-oxo-5-thia-2-azaspiro[3.4]octane 5,5-dioxide; tert-Butyl 8-oxo-2,5-diazaspiro[3.4]octane-2-carboxylate 5,5-dioxide (common misnomer); 5-Thia-2-azaspiro[3.4]octane-2-carboxylic acid, 8-oxo-, 1,1-dioxide, 2-(1,1-dimethylethyl) ester; Boc-Protected Spirocyclic Sulfonamide; 1340481-91-5; AS-1383982; AKOS040759230; ZINC000257777176
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Oxo-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, it is recommended to handle it under an inert atmosphere for extended storage or after opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.