Description

tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and sulfone-containing heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D teams and process chemists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular scaffolds with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities (NCEs) and optimize lead compounds.
• Process Development: Serves as a critical starting material or intermediate in the scale-up and optimization of API manufacturing processes.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structural features make it a potential component for designing linkers or warheads in targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A valuable substrate for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide
CAS No.	1340481-90-4
Molecular Formula	C11H19NO5S
Molecular Weight	277.34 g/mol
Synonyms	tert-Butyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-hydroxy-5-thia-, 5,5-dioxide, 1,1-dimethylethyl ester; 8-Hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester 5,5-dioxide; 1,1-Dimethylethyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide; tert-Butyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate S,S-dioxide; Spirocyclic sulfone intermediate 1340481-90-4
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.