Description

tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system and metabolic disorders. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those with spirocyclic or constrained ring systems.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in targeted protein degradation platforms.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry: Investigated for scalable synthesis routes in the development of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in universities and research institutes for methodological studies in heterocyclic and spiro compound synthesis.

Basic Information

Product Name	tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1340481-89-1
Molecular Formula	C11H19NO3S
Molecular Weight	245.34 g/mol
Synonyms	8-Hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; tert-Butyl 8-hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-hydroxy-5-thia-, 1,1-dimethylethyl ester; 5-Thia-2-azaspiro[3.4]octane-2-carboxylic acid, 8-hydroxy-, tert-butyl ester; Spirocyclic thia-azetidine carboxylate; BOC-protected hydroxy thia-azaspirooctane
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Hydroxy-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and rigorous quality control ensures material integrity for your most demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.