Description

tert-Butyl 8-Amino-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic sulfonamide scaffold. This compound is of significant value in medicinal chemistry for constructing novel molecular architectures with potential biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel small molecule drug candidates, especially protease inhibitors and kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its constrained spirocyclic structure.
• Protease Inhibitor Scaffold: The sulfonamide and spirocyclic features make it a valuable precursor for compounds targeting various enzymatic pathways.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study biological targets and mechanisms.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.
• Custom Synthesis: A starting material for the contract manufacturing of specialized APIs and advanced intermediates under cGMP conditions.

Basic Information

Product Name	tert-Butyl 8-Amino-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide
CAS No.	1340481-83-5
Molecular Formula	C11H20N2O4S
Molecular Weight	276.35 g/mol
Synonyms	8-Amino-2-(tert-butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane 5,5-dioxide; tert-Butyl 8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate S,S-dioxide; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-amino-5-thia-, 1,1-dimethylethyl ester, 5,5-dioxide; 8-Amino-2-Boc-5-thia-2-azaspiro[3.4]octane 5,5-dioxide; 8-Amino-2-N-Boc-5-thia-2-azaspiro[3.4]octane 5,5-dioxide; Boc-8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Amino-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and production needs with material suitable for research use and can supply grades aligned with cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.