Description

tert-Butyl 8-(((Benzyloxy)Carbonyl)Amino)-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic sulfonamide structure. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting challenging disease pathways. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing spirocyclic and sulfonamide motifs.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for developing new drug candidates in areas such as oncology, neurology, and immunology.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glue Development: Utilized in the construction of sophisticated bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Acts as a precursor for creating tool compounds to study specific biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-complexity intermediates.

Basic Information

Product Name	tert-Butyl 8-(((Benzyloxy)Carbonyl)Amino)-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide
CAS No.	1340481-82-4
Molecular Formula	C19H26N2O6S
Molecular Weight	410.49 g/mol
Synonyms	tert-Butyl 8-(((benzyloxy)carbonyl)amino)-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide; 2-Azaspiro[3.4]octane-2-carboxylic acid, 8-[[(phenylmethoxy)carbonyl]amino]-5-thia-, 1,1-dioxide, 1,1-dimethylethyl ester; 8-(N-Cbz-amino)-2-(tert-butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane 5,5-dioxide; Cbz-Protected Spirocyclic Sulfonamide Ester; tert-Butyl N-Cbz-8-amino-5-thia-2-azaspiro[3.4]octane-2-carboxylate S,S-dioxide
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-(((Benzyloxy)Carbonyl)Amino)-5-Thia-2-Azaspiro[3.4]Octane-2-Carboxylate 5,5-Dioxide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant quality management standards to support our global pharmaceutical and biotech clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.