Description

2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid 5,5-Dioxide is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and sulfone-containing scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting challenging disease pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those requiring spirocyclic or constrained ring systems.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteolytic enzymes, leveraging the sulfone moiety as a transition-state mimic.
• Chemical Biology Probes: Serves as a core structure for creating tool compounds to study biological pathways and protein function.
• Peptidomimetic Synthesis: Facilitates the creation of peptidomimetics with enhanced metabolic stability and bioavailability.
• Library Synthesis for HTS: An important scaffold for generating diverse compound libraries used in high-throughput screening campaigns.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid 5,5-Dioxide
CAS No.	1340481-81-3
Molecular Formula	C12H19NO6S
Molecular Weight	305.35 g/mol
Synonyms	Boc-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid 5,5-Dioxide; 2-((tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid 5,5-dioxide; 2-(Boc)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid S,S-Dioxide; 2-(tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid S,S-dioxide; 2-(tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid sulfone; Spirocyclic Sulfone Boc-Amino Acid; tert-Butyl 8-carboxy-5,5-dioxido-5-thia-2-azaspiro[3.4]octane-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 2-(tert-Butoxycarbonyl)-5-Thia-2-Azaspiro[3.4]Octane-8-Carboxylic Acid 5,5-Dioxide is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.