Description

2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate 5,5-Dioxide is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic sulfonamide scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially in areas like central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting protease inhibition or receptor modulation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained, three-dimensional spirocyclic structure.
• Sulfonamide-Based Drug Development: Serves as a core scaffold for developing new sulfonamide derivatives with potential therapeutic applications.
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects undertaken by CDMOs (Contract Development and Manufacturing Organizations).
• Academic Research: Employed in university and institutional labs for methodological development in heterocyclic and spiro compound chemistry.

Basic Information

Product Name	2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate 5,5-Dioxide
CAS No.	1340481-80-2
Molecular Formula	C13H21NO6S
Molecular Weight	319.38 g/mol
Synonyms	2-(tert-Butyl) 8-methyl 5-thia-2-azaspiro[3.4]octane-2,8-dicarboxylate 5,5-dioxide; tert-Butyl 8-methyl 5-thia-2-azaspiro[3.4]octane-2,8-dicarboxylate 5,5-dioxide; 5-Thia-2-azaspiro[3.4]octane-2,8-dicarboxylic acid, 5,5-dioxide, 2-(1,1-dimethylethyl) 8-methyl ester; Spirocyclic Sulfonamide Ester; CAS 1340481-80-2
EINECS	Contact for details

Quality Control

Every batch of 2-tert-Butyl 8-Methyl 5-Thia-2-Azaspiro[3.4]Octane-2,8-Dicarboxylate 5,5-Dioxide is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.