Description

tert-Butyl (2S)-2-(Hydroxymethyl)-2-Methylpyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected amino alcohol derivative. This compound is essential for the synthesis of complex molecules, offering a protected amine and a versatile hydroxymethyl handle for further functionalization. It is primarily used by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Peptide Mimetics & Proline Derivatives: Serves as a crucial building block for constructing peptidomimetics and modified proline analogs with enhanced biological activity.
• Asymmetric Catalysis Ligand Precursor: Used in the preparation of chiral ligands and organocatalysts for enantioselective synthesis.
• Agrochemical Synthesis: Employed in the research and development of advanced, chiral pesticides and herbicides.
• Custom Chemical Synthesis: Provides a versatile scaffold for contract research organizations (CROs) and CDMOs performing bespoke synthesis projects.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	tert-Butyl (2S)-2-(Hydroxymethyl)-2-Methylpyrrolidine-1-Carboxylate
CAS No.	1339022-10-4
Molecular Formula	C11H21NO3
Molecular Weight	215.29 g/mol
Synonyms	(2S)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)-2-methylpyrrolidine; (S)-1-Boc-2-(hydroxymethyl)-2-methylpyrrolidine; (S)-tert-Butyl 2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate; 1-Boc-2-(hydroxymethyl)-2-methylpyrrolidine (S-enantiomer); (S)-2-Methyl-2-pyrrolidinemethanol, 1-Boc-protected; Boc-L-2-(Hydroxymethyl)-2-methylpyrrolidine; (S)-1-N-Boc-2-(hydroxymethyl)-2-methylpyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl (2S)-2-(Hydroxymethyl)-2-Methylpyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and advanced synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.