Description

n-Cyclopropyl-5-Iodo-2-Aminopyridine is a high-purity, functionalized pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique halogenated and aminated structure, which provides versatile reactivity for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its modifiable iodine and amine functional groups.
• Agrochemical Development: Serves as a building block for creating new crop protection agents and pesticides.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl and other conjugated systems.
• Ligand Synthesis: Utilized in the preparation of specialized nitrogen-containing ligands for catalysis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and photoactive compounds.

Basic Information

Product Name	n-Cyclopropyl-5-Iodo-2-Aminopyridine
CAS No.	1338247-41-8
Molecular Formula	C8H9IN2
Molecular Weight	260.08 g/mol
Synonyms	5-Iodo-2-amino-N-cyclopropylpyridine; 2-Amino-5-iodo-N-cyclopropylpyridine; 2-Pyridinamine, 5-iodo-N-cyclopropyl-; 5-Iodo-N-cyclopropylpyridin-2-amine; n-Cyclopropyl-5-iodopyridin-2-amine; 1338247-41-8; 5-Iodo-2-(cyclopropylamino)pyridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Standard quality control for this advanced intermediate includes verification of identity, purity, and impurity profile. Certificates of Analysis (COA) are available upon request, detailing batch-specific results from analytical methods such as HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.