Description

n-Boc-1-(2-Amino-Ethyl)-Piperidin-3-One is a high-purity, protected piperidinone derivative featuring both a Boc-protected amine and a free primary amine, making it a versatile and critical building block in synthetic organic chemistry. Its value lies in its bifunctional nature, enabling its use as a key intermediate for constructing complex molecular scaffolds, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on the synthesis of novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and other disease modalities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules designed to inhibit specific proteolytic enzymes.
• Kinase Inhibitor Development: Serves as a core scaffold or side-chain component in the creation of potential kinase inhibitors for oncology and other therapeutic areas.
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes for studying biological pathways and target engagement.
• Peptidomimetic Research: Integral for designing and synthesizing peptide-like molecules with enhanced stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects and scale-up activities.

Basic Information

Product Name	n-Boc-1-(2-Amino-Ethyl)-Piperidin-3-One
CAS No.	1337882-51-5
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	1-(2-Aminoethyl)-3-piperidinone, 1-Boc derivative; tert-Butyl 1-(2-aminoethyl)-3-oxopiperidine-1-carboxylate; 3-Oxo-1-piperidineacetic acid, 1-(1,1-dimethylethoxy)carbonyl-, β-amino-; 1-Boc-3-oxo-1-piperidineacetamide, N-unsubstituted; N-Boc-1-(2-aminoethyl)piperidin-3-one; 1-(tert-Butoxycarbonyl)-1-(2-aminoethyl)piperidin-3-one; (2-((1-(tert-Butoxycarbonyl)-3-oxopiperidin-1-yl)ethyl)amine
EINECS	Contact for details

Quality Control

Our n-Boc-1-(2-Amino-Ethyl)-Piperidin-3-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.