Description

4-Azido-2-Chloropyridine-3-Carbaldehyde is a versatile and highly reactive heterocyclic building block. This compound matters for its unique bifunctional reactivity, combining an azido group for click chemistry and an aldehyde moiety for condensation reactions, enabling the rapid synthesis of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel pyridine-based scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other biologically active heterocycles.
• Click Chemistry Reagent: The azido group enables efficient, high-yielding Huisgen 1,3-dipolar cycloaddition reactions (copper-catalyzed or strain-promoted) for bioconjugation and polymer functionalization.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that incorporate functionalized pyridine cores.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts.
• Materials Science: Employed in the preparation of functional polymers, dendrimers, and smart materials via its reactive handles.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes for target identification and validation.

Basic Information

Product Name	4-Azido-2-Chloropyridine-3-Carbaldehyde
CAS No.	1337881-90-9
Molecular Formula	C6H2ClN4O
Molecular Weight	181.56 g/mol
Synonyms	2-Chloro-4-azidopyridine-3-carboxaldehyde; 3-Formyl-2-chloro-4-azidopyridine; 4-Azido-2-chloro-3-pyridinecarboxaldehyde; 2-Chloro-4-azido-3-pyridinecarbaldehyde; 4-Azido-2-chloronicotinaldehyde; 2-Chloro-4-azidonicotinaldehyde; 3-Pyridinecarboxaldehyde, 4-azido-2-chloro-
EINECS	Contact for details

Quality Control

Our 4-Azido-2-Chloropyridine-3-Carbaldehyde is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and FTIR, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and thermal degradation. Keep away from heat, sparks, and open flame. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.