Description

8-Carboxy-1-Chloroisoquinoline, also known as 8-Carboxy-1-Chloro-2-Azanaphthalene, is a high-purity, multi-functional heterocyclic building block with significant synthetic utility. This compound is valued for its dual reactive sites—the carboxylic acid and the chlorinated aromatic ring—which enable its use in constructing complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Acts as a building block for organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and for the introduction of the isoquinoline pharmacophore into target molecules.
• Chemical Biology: Utilized in the synthesis of probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring functionalized isoquinoline derivatives.

Basic Information

Product Name	8-Carboxy-1-Chloroisoquinoline
CAS No.	1337879-52-3
Molecular Formula	C10H6ClNO2
Molecular Weight	207.61 g/mol
Synonyms	8-Carboxy-1-Chloro-2-azanaphthalene; 1-Chloro-8-isoquinolinecarboxylic acid; 1-Chloroisoquinoline-8-carboxylic acid; 8-Carboxy-1-chloroisoquinoline; 1-Chloro-2-azanaphthalene-8-carboxylic acid; 8-Isoquinolinecarboxylic acid, 1-chloro-; 1337879-52-3
EINECS	Contact for details

Quality Control

Our 8-Carboxy-1-Chloroisoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.