Description

1-[5-(4-Amino-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)-2,3-Dihydro-1H-Indol-1-Yl]-2-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Ethanone is a high-purity, advanced pharmaceutical intermediate designed for precision synthesis. This compound is critical for research and development in targeted drug discovery programs, particularly those focused on kinase inhibition. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational kinase inhibitors for oncology and inflammatory diseases.
• Biochemical Research: Used as a reference standard or a precursor in structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a critical material for process chemistry development and scale-up studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and drug discovery projects.

Basic Information

Product Name	1-[5-(4-Amino-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)-2,3-Dihydro-1H-Indol-1-Yl]-2-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Ethanone
CAS No.	1337531-89-1
Molecular Formula	C24H19F4N5O
Molecular Weight	469.44 g/mol
Synonyms	1337531-89-1; 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone; 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethan-1-one; Kinase Inhibitor Intermediate; Pyrrolopyrimidine-Indole Derivative
EINECS	Contact for details

Quality Control

Our 1-[5-(4-Amino-7-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-5-Yl)-2,3-Dihydro-1H-Indol-1-Yl]-2-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.