Description

Azido-Peg3-Phosphonic Acid Ethyl Ester is a specialized bifunctional linker molecule featuring an azide group and a phosphonic acid ethyl ester, connected by a triethylene glycol (PEG3) spacer. This compound is engineered to facilitate efficient bioconjugation and surface modification through click chemistry and metal-oxide binding, respectively. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, materials science, and nanotechnology, enabling the precise attachment of biomolecules, drugs, or probes to various substrates.

Application

• Bioconjugation and Click Chemistry: The azide group enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) for labeling proteins, antibodies, oligonucleotides, and small molecule drugs.
• Surface Functionalization: The phosphonic acid ester moiety allows for stable binding to metal oxide surfaces (e.g., TiO2, ZrO2, ITO), creating biofunctionalized platforms for biosensors, implants, and diagnostic devices.
• Drug Delivery System Development: Used to create targeted drug conjugates or to functionalize nanoparticle surfaces (e.g., iron oxide, silica) for enhanced therapeutic delivery and specificity.
• Proteomics and Chemical Biology: Serves as a versatile tool for introducing chemical handles into biological systems for pull-down assays, activity-based protein profiling, and imaging studies.
• Polymer and Material Science: Acts as a crosslinker or modifier to introduce reactive azide groups into polymers, hydrogels, and coatings for advanced material properties.
• Diagnostic Reagent Synthesis: Employed in the synthesis of contrast agents, fluorescent probes, and other diagnostic tools requiring specific surface attachment.

Basic Information

Product Name	Azido-Peg3-Phosphonic Acid Ethyl Ester
CAS No.	1337527-24-8
Molecular Formula	C11H24N3O7P
Molecular Weight	341.30 g/mol
Synonyms	Azido-PEG3-phosphonic acid ethyl ester; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethylphosphonic acid ethyl ester; Ethyl 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylphosphonate; Azido-triethylene glycol phosphonic acid ethyl ester; N3-PEG3-phosphonic acid ethyl ester; Azido-PEG3-P(O)(OEt)2; Phosphonic acid, P-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Azido-Peg3-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.