Description

5-Bromo-2-Chloronicotinic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a versatile building block in the synthesis of complex molecules, particularly in the creation of active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and manufacturing organizations in the pharmaceutical, agrochemical, and fine chemical sectors seeking reliable, high-quality raw materials for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated nicotinic acid structure.
• Chemical Research & Development: Serves as a versatile reagent in academic and industrial R&D labs for exploring new organic reactions and methodologies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the synthetic pathway for producing complex APIs that require specific halogenated pyridine motifs.
• Ligand and Catalyst Preparation: Utilized in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions, which are fundamental in modern organic synthesis.

Basic Information

Product Name	5-Bromo-2-Chloronicotinic Acid tert-Butyl Ester
CAS No.	1335055-73-6
Molecular Formula	C10H11BrClNO2
Molecular Weight	292.56 g/mol
Synonyms	tert-Butyl 5-bromo-2-chloronicotinate; 2-Chloro-5-bromonicotinic acid tert-butyl ester; 5-Bromo-2-chloro-3-pyridinecarboxylic acid 1,1-dimethylethyl ester; Nicotinic acid, 5-bromo-2-chloro-, 1,1-dimethylethyl ester; 3-Pyridinecarboxylic acid, 5-bromo-2-chloro-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloronicotinic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical and fine chemical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to support customer needs for regulatory documentation and supply chain transparency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. Handle and store in accordance with good laboratory/manufacturing practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.