Description

5-(Benzyloxy)-2-Bromo-3-Chloropyridine is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and ether functionalities into their target structures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides requiring halogenated pyridine cores.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, process chemistry, and exploring new synthetic methodologies in academic and industrial labs.
• Ligand Synthesis: Used to prepare complex chelating ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-(Benzyloxy)-2-Bromo-3-Chloropyridine
CAS No.	1335052-36-2
Molecular Formula	C12H9BrClNO
Molecular Weight	298.56 g/mol
Synonyms	2-Bromo-3-chloro-5-(phenylmethoxy)pyridine; 3-Chloro-2-bromo-5-benzyloxypyridine; 5-Benzyloxy-2-bromo-3-chloropyridine; 2-Bromo-3-chloro-5-(benzyloxy)pyridine; Pyridine, 2-bromo-3-chloro-5-(phenylmethoxy)-; 1335052-36-2
EINECS	Contact for details

Quality Control

Our 5-(Benzyloxy)-2-Bromo-3-Chloropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.